Curcumin and a novel phage act synergistically against multidrug-resistant Acinetobacter baumannii (Scientific Reports)

In vitro, curcumin (400 ug/mL) combined with the newly isolated phage vB_AbaSI_1 reduced multidrug-resistant A. baumannii to undetectable levels within 1 hour, and a double dose extended this to 5 hours, whereas phage alone rebounded within 3 hours. Synergy occurred only with phage-susceptible strains; the authors say future work will engineer the phage to make it therapeutically acceptable.