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How should we optimally design phage cocktail timing and dosage to deal with evolutionary escape of pathogens? Guanlin Li and Chung Yin Leung (Georgia Institute of Technology) and colleagues published a new paper on using mathematical modeling to optimize phage cocktail design. They show that optimized single-strain phage therapy may cure infections in immunocompetent patients, but may fail in immunodeficient hosts, though including a counter-resistant phage could restore therapeutic efficacy. Paper | Earlier preprint.