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In a recent podcast episode of This Week in Virology (TWiV), learn how a viral capsid protein activates a bacterial innate immune system, interfering with protein synthesis, and human-associated redondoviruses that infect the commensal protozoan Entamoeba gingivalis. Hosted by Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Jolene Ramsey.