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Kevin Forsberg (Fred Hutchinson Cancer Research Center) and colleagues have published a new paper in eLife on a high-throughput method to find new phage-encoded anti-CRISPR proteins. The method involves expressing gene fragments from human oral and fecal metagenomes in E. coli and screening for Cas9-inhibitory activity. Excitingly, they found a new anti-CRISPR protein that inhibits Cas9 by a new mechanism, and works on divergent Cas9s.