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Maria Loose (Justus-Liebig University Giessen, Germany) and colleagues published a new paper in Antibiotics showing natural bred ε2-phages have improved host range and virulence against uropathogenic Escherichia coli over their ancestor phages. The authors isolated phages and conducted experiments to increase the phage host range and virulence. They found that phages were mosaics of their ancestors, with extensive recombinations.