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Patrick Pausch (UC Berkeley) and colleagues have published a new paper in Science on a new 'minimal functional' CRISPR-Cas system comprised of a single 70-kDa protein, CasΦ, that they discovered in phages. This system is active in human and plant cells, has expanded target recognition capacity, and is half the molecular weight of Cas9 and Cas12a, making it extra advantageous for genome editing.