PHAG-ONE: France's first public GMP platform for therapeutic phages

The ANR-supported PHAG-ONE project, led by Prof. Frédéric Laurent (Hospices Civils de Lyon), is creating a national public infrastructure for GMP-grade production of therapeutic phages. The platform has produced three GMP pilot batches of four phages targeting Staphylococcus aureus that collectively cover 88% of the species' genetic and clinical diversity; compassionate-use treatments, cohort monitoring and preparation of clinical trials come next.