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Phil Huss (University of Wisconsin-Madison) and colleagues published a new paper in eLife describing their use of deep mutational scanning to map the functional landscape of the T7 phage receptor binding domain. Using this high-throughput, locus-specific phage engineering method, they systematically dissected the functional role of every residue in the tip domain of T7 phage RBP. This then allowed them to engineer T7 variants that were more highly active against E. coli.