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It's recently been discovered that during replication, some jumbo phages (genomes > 200 kb) establish complex subcellular organization within their host. Vorrapon Chaikeeratisak (University of California San Diego) and colleagues published a new minireview in Frontiers in Microbiology on what's currently understood about jumbo phages that form a nucleus-like structure, or 'phage nucleus' during replication.