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Adair Borges and colleagues from the Bondy-Denomy lab at UCSF have published a paper discussing how Pseudomonas aeruginosa host factors, previously characterized for their role in alginate biosynthesis, affect its Type I-F CRISPR–Cas system. The presence of homologs of alginate regulators in Pseudomonas phages suggests they can adapt this regulation mechanism to repress CRISPR-Cas immunity.