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In this Nature Communications paper, Brieuc Van Nieuwenhuyse (Université Catholique de Louvain) and colleagues report the story of a toddler who suffered from extensively drug-resistant Pseudomonas aeruginosa sepsis after liver transplantation. He was treated by a bacteriophage-antibiotic intravenous combination therapy for 86 days, which was associated with objective clinical and microbiological improvement.