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Yi Duan (UCSD) and colleagues have published an incredibly exciting paper showing that cytotoxin-secreting Enterococcus faecalis in the mouse gut is a cause of alcohol-induced liver disease in mice. Most excitingly, they used phages to target cytotoxin-positive E. faecalis, and found that this abolished alcohol-induced liver disease in the mice! This is a great example of what microbiome-editing could look like, and shows the potential promise of phages (next step: testing this in humans). Paper | Commentary by Martha Clokie
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| Source | Capsid & Tail #52 |
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