Programs and studies

Clinical study

Bacteriophage Therapy in Tonsillitis

StatusActive, not recruiting
TypeTrial
CountriesUzbekistan
Conditions studiedAcute Tonsillitis
Study years2020–2028 (estimated)
Entry review2026-10-03

Participation

Check the study record or contact the study team for current recruitment and eligibility.

Study eligibility

Inclusion Criteria: * children from 3 to 14 years old. * children with sore throat. * children diagnosed with acute tonsillitis. * children diagnosed with acute respiratory infection (rhinitis, sinusitis, nasopharyngitis). * children with the opportunity to visit the outpatient clinic. * children with the ability to receive inhalation therapy. * children from parents (or guardians) who have given written permission to conduct clinical and laboratory research. Exclusion Criteria: * children under 3 years old and over 14 years old. * children receiving hospital treatment. * children with acute respiratory tract diseases (bronchitis, pneumonia, pleurisy). * children with сhronic respiratory tract diseases (bronchitis, pneumonia). * children who are allergic to antibiotics. * children with cancer, immunological and hematological diseases. * children with severe psychological illnesses (schizophrenia, mental retardation, etc.) * children with cancer, immunological and hematological diseases. * children with tuberculosis.

Study description

The patients received bacteriophage therapy with a liquid piobacteriophage complex (liquid pyobacteriophage complex - PCL). PСL was administered via nebulizer inhalation to irrigate the tonsil mucosa. A total of 5 ml of PCL was inhaled for 10 minutes every 5 days. The drug causes the lysis of certain bacteria, including staphylococcus, enterococcus, streptococcus, enteropathogenic E. coli, Proteus vulgaris, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae and Klebsiella oxytoca. The choice of this drug was based on bacteriological studies.

Study registrations

ClinicalTrials.govNCT04682964
Recorded study locations (1)

Locations listed in the study record; this does not confirm current recruitment or treatment outside the study. A site label may be older than the overall study status.

Tashkent Pediatric Medical Institute

Tashkent, Uzbekistan

Recorded site status: Not separately listed. Study location source ↗

Sources and updates

Entry reviewed . This is the date of our source review, not a confirmation of availability today.

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Study ID
nct04682964