Jessica Sacher, PhD

Phage Directory (Co-founder); Stanford University (Staff Scientist); Bollyky Lab

I'm a co-founder of Phage Directory and have a PhD in Microbiology from the University of Alberta (I studied Campylobacter phage biology).

For Phage Directory, I help physicians find phages for their patients, and I'm always trying to find new ways to help the phage field grow (especially through connecting people and highlighting awesome stuff I see happening in the field).

I spent 2022-2024 as a postdoc in Jon Iredell's group at Westmead Institute for Medical Research in Sydney, Australia, helping get Phage Australia off the ground. I helped set up workflows for phage sourcing, biobanking, diagnostics, production, purification and QC of therapeutic phage batches, and helped build data collection systems to track everything we did. We treated more than a dozen patients in our first year, and I'm so proud of that!

As of 2024, I joined the Bollyky lab at Stanford University as a Staff Scientist, where I'm focused on building the Stanford Center for Phage Pharmaceuticals. The ‘Phage Pharm’ will be a home for innovative phage pharmacodynamics and phage-immune interactions research, with a focus on translating findings directly to the bedside and back to the bench.

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  1. Our Phage Picks for December 2024!Phage + machine learning = amazing strides, yet again! From creating synthetic genomes to building smarter experiments, this month’s Phage Picks issue explores some key papers Jess & Jan keep coming back to!Issue 294Jessica Sacher
  2. A Mayo Clinic Physician's Journey with Phage TherapyWhat's it like treating patients with phages at a major US medical center? In a new Podovirus Podcast episode, Mayo Clinic's Dr. Gina Suh shares insights from 5 years of phage therapy — the successes, the challenges, and what it takes to…Issue 289Jessica Sacher
  3. How Eligo Bioscience edits gut bacteria with phagesHow can we harness phage-based technologies to edit bacterial genes in the microbiome? Jesus Fernandez of Eligo Biosciences shares how they're modifying phages to base-edit mouse gut bacteria, and how that opens up new possibilities for…Issue 284Jessica Sacher
  4. C&T Round Up for August 2024!This month, we recap what we learned about AI spreadsheet tools, how phage funding has changed over the years, and the rise of phage research in Latin America!Issue 279Jessica Sacher
  5. Getting phage research funded: Joe Campbell reflects on a career at NIAIDHow do we get our phage grants funded? We start by getting to know our program officers! Joe Campbell has played a key role in shaping phage research funding for the last decade during his time at NIAID, and this week shares how he sees the…Issue 277Jessica Sacher
  6. N of 1 trials vs. compassionate use for phage therapyWhat are 'n of 1' clinical trials, how do they compare to compassionate use, and how might they be used for phages? This week Jessica shares musings about this topic, which has been swirling in her brain for a while now...Issue 274Jessica Sacher
  7. Our Phage Picks for July 2024!It's Phage Picks time! This week we've got the fifth rendition of our new format, where we share the papers we keep bookmarked, and keep coming back to.Issue 273Jan Zheng, Jessica Sacher
  8. Our Phage Picks for May 2024!Here's the third rendition of our new format: Phage Picks — where we share the papers we keep bookmarked... and keep coming back to.Issue 264Jan Zheng, Jessica Sacher
  9. Why all phage researchers need to be in Australia this JulyThis week we've got an interview with Jeremy Barr on what to expect this year at the Viruses of Microbes conference in Cairns, Australia! From Great Barrier Reef, to crocodile jet ski stories, to special ways they're making the conference…Issue 263Jessica Sacher, Jeremy Barr
  10. Setting up systems to make phages available for allSix years ago, just as I was finishing up my microbiology PhD, I stumbled across an opportunity to help a patient. One patient turned into many, and what I used to think was 50 years away — using phages to treat infections — has become my…Issue 261Jessica Sacher
  11. What do we know about phages and neutrophils?There's been a few studies lately on phages and neutrophils. Do they help each other? Do they get in each other's way? Who can keep track? This week we take a look at three phage-neutrophil papers and what they found.Issue 260Jessica Sacher
  12. Our Phage Picks for April 2024!Here's the second rendition of our new format: Phage Picks — where we share the papers we keep bookmarked... and keep coming back to.Issue 259Jan Zheng, Jessica Sacher
  13. How a prophage controls fly reproductionThis week we're highlighting a brand new paper out of the Bordenstein lab, out yesterday in Science, that unravels the mechanism by which prophage-encoded proteins control whether Drosophila flies reproduce or not.Issue 255Jessica Sacher
  14. Our Phage Picks for March 2024!We're starting off the year by trying a new format: Phage Picks — where we share the papers we keep bookmarked... and keep coming back to.Issue 254Jan Zheng, Jessica Sacher
  15. We're back! Hello 2024!We’re excited to embark on another new chapter this year, this time in the San Francisco Bay Area! Here’s some reflections on the transition now that we’re stateside, what we’re thinking about these days, and a sneak peek into what’s in…Issue 253Jessica Sacher
  16. Year in Review 2023This week we wrap up 2023 and reflect on our biggest surprises and proudest moments! Things are also changing in 2024...Issue 252Jan Zheng, Jessica Sacher
  17. Lessons from viral vectors, CAR-T, & RNAPhage production has its quirks, but it’s not the only field trying to reliably manufacture a new biological entity. This week Jessica shares learnings from Australia’s annual bioprocessing conference about challenges other fields are…Issue 249Jessica Sacher
  18. ChatGPT tips for lab workThis week, we get to explore and share some ideas about how to (responsibly) use ChatGPT for lab work!Issue 243Jan Zheng, Jessica Sacher
  19. Making our phage therapy process more efficientThis week Jessica Sacher shares ways the Phage Australia lab team has been improving efficiency of its phage therapy system, such as dividing up work, managing expectations, overcommunicating with clinical teams, and setting up solid lab…Issue 239Jessica Sacher
  20. How our phage therapy system works at Phage AustraliaAt Phage Australia, we're scaling up personalized phage therapy. Jessica Sacher shares an overview of the process, to assist other centers in navigating the challenges of running a successful phage therapy (or other bio-based) service.Issue 231Jessica Sacher